England will open their Nations Championship campaign with a 2019 World Cup final rematch against South Africa on July 4 in Johannesburg.
Steve Borthwick's side face a stern test against the reigning world champions, before taking on Fiji and Argentina in their two remaining summer fixtures in the southern hemisphere.
The tournament also sees the Springboks face Wales and Scotland, while Ireland play Australia and Japan before a trip to Auckland to tackle New Zealand in a mouth-watering contest. Scotland and Wales meet Argentina and Fiji in their other southern hemisphere matches.
Elsewhere, a vaunted France side also face New Zealand in their first game since their victorious Six Nations campaign for what will be a heavyweight clash at the One New Zealand stadium in Christchurch.
The three summer game weeks are the first part of the tournament, which resumes in November with the northern hemisphere edition in which England are set to host New Zealand, Australia and Japan at Twickenham.
After the six gameweeks conclude, a finals weekend at Twickenham will see each team play their equivalent in the other hemisphere, concluding with the first-placed northern hemisphere side playing the first-placed southern hemisphere side on November 29. A Ryder Cup-style points system will decide the winner of the first hemisphere trophy.
Saturday 4 July
New Zealand v France; 08:10 BST
Japan v Italy; 09:40 BST
Australia v Ireland; 11:10 BST
Fiji v Wales; 14:10 BST
South Africa v England; 16:40 BST
Argentina v Scotland; 20:10 BST
Saturday 11 July
New Zealand v Italy; 06:10 BST
Australia v France; 08:40 BST
Japan v Ireland; 11:10 BST
Fiji v England; 14:10 BST
South Africa v Scotland; 16:40 BST
Argentina v Wales; 20:10 BST
Saturday 18 July
New Zealand v Ireland; 08:10 BST
Japan v France; 09:40 BST
Australia v Italy; 11:10 BST
Fiji v Scotland; 14:10 BST
South Africa v Wales; 16:40 BST
Argentina v England; 20:10 BST
Friday 6 November
Ireland v Argentina; 20:10 GMT
Saturday 7 November
Italy v South Africa 11:40 GMT
Scotland v New Zealand; 14:10 GMT
Wales v Japan; 16:40 GMT
France v Fiji; 20:10 GMT
Sunday 8 November
England v Australia; 15:10 GMT
Friday 13 November
France v South Africa; 20:10 GMT
Saturday 14 November
Italy v Argentina; 11:40 GMT
Wales v New Zealand; 14:10 GMT
England v Japan; 16:40 GMT
Ireland v Fiji; 20:10 GMT
Sunday 15 November
Scotland v Australia; 15:10 GMT
Saturday 21 November
England v New Zealand; 14:10 GMT
Scotland v Japan; 14:10 GMT
Ireland v South Africa; 16:40 GMT
Italy v Fiji; 16:40 GMT
France v Argentina; 20:10 GMT
Wales v Australia; 20:10 GMT
Finals
Friday 27 November
Sixth-placed northern hemisphere side v Sixth-placed southern hemisphere side; 16:40 GMT
Third-placed northern hemisphere side v Third-placed southern hemisphere side; 20:10 GMT
Saturday 28 November
Fifth-placed northern hemisphere side v Fifth-placed southern hemisphere side; 13:10 GMT
Second-placed northern hemisphere side v Second-placed southern hemisphere side 16:40 GMT
Sunday 29 November
Fourth-placed northern hemisphere side v Fourth-placed southern hemisphere side; 13:10 GMT
First-placed northern hemisphere side v First-placed southern hemisphere side; 16:40 GMT
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